The area covers a total land area of 132,288 km² including the San Andres Island in the Caribbean sea and corresponding to approximately 1/10 of the total territory of Colombia. The Caribbean Region of Colombia is home to approximately 9 million people according to the Colombian Census 2005.

The area is characterized for having a massif plain that extends from the Colombian Andean Mountain range, surrounds the Sierra Nevada de Santa Marta mountain range and covers the Guajira Peninsula to border the Caribbean sea. In the western side of the region there is also a relative low altitude mountain range, the Montes de Maria which are also separate from the Andean mountain range. The Caribbean Region is crossed by many rivers and contains one of the largest marshes in Colombia, the Ciénaga Grande de Santa Marta marsh among many others. The main river is the Magdalena River which is fully navigable in the region and a major path for the flow of shipments from and for inland Colombia. The Madgalena river has numerous sub basins within its basin.

The Caribbean Region coast extends from the Gulf of Uraba to the Gulf of Venezuela with the main port cities of Barranquilla and Cartagena bordering it. The administration of the region is covered by eight department governments; Atlántico, Bolívar, Cesar, Sucre, Córdoba, Magdalena, La Guajira and San Andrés y Providencia. These 8 departments also cover approximately 182 municipalities, 1093 corregimientos and 493 caserios according to the 2005 Census by DANE. Most of its inhabitants speak a dialect of Caribbean Spanish with variations within its subregions.