It is located in the northern part of the country, in the Pannonian plain of Central Europe. Its capital and largest city is Novi Sad, at over 300,000 people, while its second largest city is Subotica. Vojvodina has six official languages, and there are more than 26 ethnic groups in the region.

Vojvodina is situated in the northern part of Serbia. The region is divided by the Danube and Tisa rivers into: Bačka in the northwest, Banat in the east and Syrmia (Srem) in the southwest. A small part of the Mačva region is also located in Vojvodina, in the Srem District. Today, the western part of Syrmia is in Croatia, the northern part of Bačka is in Hungary, the eastern part of Banat is in Romania (with a small piece in Hungary), while Baranja (which is between the Danube and the Drava) is in Hungary and Croatia. Vojvodina has a total surface area of 21,500 km² (8,299 mi²). Vojvodina is also part of the Danube-Kris-Mures-Tisa euroregion.